Editors: Sensationalized: AP Says Fetal Stem Cells Trigger Tumors in Boy

Editors: Sensationalized: AP Says Fetal Stem Cells Trigger Tumors in Boy

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Sensationalized: AP Says Fetal Stem Cells Trigger Tumors in Boy

Stem tourism gone wrong

Editors published 2/18/2009 8:10:00 AM
Source: Report: Fetal stem cells trigger tumors in ill boy LAURAN NEERGAARD, AP Medical Writer, AP
The Associated Press has sensationalized an old stem tourism case where Russian stem therapy from 2002-2004 went horribly wrong.

An Israeli boy with a fatal brain disease developed tumors after receiving stem cell injections created from multiple fetal stem cells (some were from a female).

Doctors say his brain disease wasn't conducive to stem cell therapy in the first place.

This is the first known case of a human brain tumor complicating neural stem cell therapy.

The boy, now 17, has Ataxia Telangiectasia (A-T), a rare brain disease which degenerates a certain brain region and gradually robs these children of movement. Most die in their teens or early 20s.

The parents were desperate and traveled to a Moscow clinic in 2002, where the then 9 year old boy received an injection of neural stem cells from a fetus directly into his brain and spinal cord. He was injected again at ages 10 and 12.

At age 13, in 2006, he began to complain of headaches.

Back home in Israel at age 13, the boy's A-T was severe enough to require that he use a wheelchair when he also began complaining of headaches. Tests at Sheba Medical Center in Tel Aviv uncovered a growth pushing on his brain stem and a second on his spinal cord. Surgeons removed the spinal cord mass when the boy was 14, in 2006 and they say his general condition has remained stable since then.

But was the boy prone to tumors anyway or were the fetal stem cells to blame? A Tel Aviv University team extensively tested the tumor tissue and concluded it was the fetal cells. Among other evidence, some of the cells were female and had two normal copies of the gene that causes A-T—although that boy's underlying poor immune function could have allowed the growths to take hold.

Using stem cells from multiple fetuses that also were mixed with growth-spurring compounds "may have created a high-risk situation where abnormal growth of more than one cell occurred," wrote lead researcher Dr. Ninette Amariglio of Sheba Medical. She urged better research to "maximize the potential benefits of regenerative medicine while minimizing the risks."

This brain disease wasn't conducive to stem cell therapy in the first place, said stem cell specialist Dr. Marius Wernig of Stanford University, who said it's unclear exactly what was implanted.

"Stem cell transplantations have a humongous potential," Wernig said. But "if people rush out there without really knowing what they're doing ... that really backfires and can bring this whole field to a halt."


This is an old case which the AP has sensationalized for its own benefit.

This is a good example of the type of stem cell tourism you want to stay clear of - fetal stem cells from multiple sexes and multiple sources, from a clinic in Moscow.

The source for the AP story is Public Library of Science PLoS Medicine from 2007-2009

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